|
KMID : 0368819920310050884
|
|
Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 5 p.884 ~ p.894
|
|
|
Population Pharmacolinetics and Bayesian Feedback Method for Nortriptyline Dosage Optimisation
|
|
신상구
우종인/장인진/박찬웅/김재진/홍진표/이경훈
|
|
|
Abstract
|
|
|
The prediction performance of population kinetics and Bayesian feedback method was evaluated with respect to accuracy. Bias. correlation in 18 normal subject and 29 patients treated with nortriptyline. The root squared error(RMSE) served as a
precision.
To obtain the population kinetic parameter of nortriptyline in native Korean, NONMEM approach which including structural and statistical kinetic model was used in analysis the 250 plasma level data from 18 normal subjects after single oral dose
of
50mg.
The results obtained from the approach using population kinetics-Bayesian feedback method indicate that the future nortriptyline plasma concentration could be predicted with relatively high accuracy(34.9ng/ml) and preccision(RMSE; 25.6%)with a
signle
measurement of plasma nortriptyline level after the nortriptyline dose. The accurary(23.3ng/ml)and precision(RMSE; 15.5%) of the prediction were much more imporved with two-point measurements of plasma nortriptyline level. In conclusion,
feedback,
approach based on the population kinetic parameters seems to be accurate and reliable for predicting individual dosage requirements in patients treated with nortriptyline.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|